Organic disulfides
Medchemexpress LLC (R)-Zelebrudomide | 3024312-52-2 | C39H45N9O5 | 25 MG
(R)-Zelebrudomide, also known as (R)-NX-2127, is an isomer of the BTK PROTAC degrader Zelebrudomide. It is used in cancer research and is supplied as a light yellow to yellow solid with a purity of 98.93%. This product is for research use only and has not been fully validated for medical applications.
- Isomer of BTK PROTAC degrader Zelebrudomide
- Used in cancer research
- Supplied as a light yellow to yellow solid
- Purity of 98.93%
Medchemexpress LLC NX-2127 | 2416131-46-7 | C39H45N9O5 | 500 MG
Zelebrudomide (NX-2127) is an orally active PROTAC degrader that targets Bruton's Tyrosine Kinase (Btk). It inhibits the proliferation of BTKC481S mutant TMD8 cells more effectively than Ibrutinib. In vivo, it demonstrates potent degradation of BTK in cynomolgus monkeys and leads to superior tumor growth inhibition in both WT TMD8 and C481S mutant xenograft models in mice.
- Inhibits proliferation of BTKC481S mutant TMD8 cells
- Catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3)
- Stimulates T cell activation and increases IL-2 production
- Demonstrates potent degradation of BTK in cynomolgus monkeys
- Leads to superior tumor growth inhibition in xenograft models in mice
Medchemexpress LLC (R)-Zelebrudomide | 3024312-52-2 | C39H45N9O5 | 5 MG
(R)-Zelebrudomide is an isomer of the BTK PROTAC degrader Zelebrudomide. It is also known as (R)-NX-2127 and (R)-Compound 28. This compound includes a BTK ligand 10, (S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline, and Thalidomide 5-fluoride.
- Purity: 98.93%
- Molecular weight: 719.83
- Appearance: Light yellow to yellow solid
- Storage: 4°C, protected from light; in solvent: -80°C for 6 months or -20°C for 1 month, protected from light
Medchemexpress LLC (R)-NX-2127 | 3024312-52-2 | 98.9% | 719.83 | C39H45N9O5 | 10 MG
(R)-NX-2127 is the R-isomer of a Bruton's tyrosine kinase (BTK) PROTAC degrader supplied as a high-purity solid for preclinical research. The compound is intended for use in studies of BTK degradation and related cellular pharmacology; consult the supplier product page and SDS for handling and storage details.
- R-isomer of a BTK PROTAC degrader
- High reported purity (98.93%)
- Molecular weight 719.83
- Chemical formula C39H45N9O5
- Solid, light yellow to yellow appearance
- Recommended storage: 4°C protected from light; in solvent -80°C (6 months) or -20°C (1 month)
- Intended for preclinical BTK degradation and cellular assays
Medchemexpress LLC Luseogliflozin hydrate | 1152425-66-5 | MFCD34574461 | 99.2% | 452.56 | C23H32O7S | 5 MG
Luseogliflozin hydrate is the hydrated form of luseogliflozin, a selective sodium-glucose cotransporter 2 (SGLT2) inhibitor used in preclinical and in vitro research on glucose transport and type 2 diabetes. The compound is supplied for laboratory research with accompanying analytical and safety documentation.
- Purity 99.2%.
- Molecular weight 452.56 g/mol.
- CAS number 1152425-66-5.
- Available as a solid powder in multiple pack sizes including 5 MG.
- Analytical data available: COA, HNMR, LCMS, SDS.
- Intended for preclinical and in vitro research use only.